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Genetic disorder resulting from the combined action of alleles of more than one gene (e.g., heart disease, diabetes, and some cancers). Although such disorders are inherited, they depend on the simultaneous presence of several alleles; thus the hereditary patterns usually are more complex than those of single-gene disorders.
See also: single-gene disorder.
Industry:Biology
The use of DNA for identification. Some examples of DNA use are to establish paternity in child support cases; establish the presence of a suspect at a crime scene, and identify accident victims..
Industry:Biology
A method for amplifying a DNA base sequence using a heat-stable polymerase and two 20-base primers, one complementary to the (+) strand at one end of the sequence to be amplified and one complementary to the (-) strand at the other end. Because the newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample..
Industry:Biology
Siblings born at the same time as the result of fertilization of two ova by two sperm. They share the same genetic relationship to each other as any other siblings.
See also: identical twin.
Industry:Biology
Adding pertinent information such as gene coded for, amino acid sequence, or other commentary to the database entry of raw sequence of DNA bases.
See also: bioinformatics.
Industry:Biology
Difference in DNA sequence among individuals that may underlie differences in health. Genetic variations occurring in more than 1% of a population would be considered useful polymorphisms for genetic linkage analysis.
See also: mutation.
Industry:Biology
The complete order of bases in a gene. This order determines which protein a gene will produce..
Industry:Biology
Each generation of offspring has increased severity of a genetic disorder; e.g., a grandchild may have earlier onset and more severe symptoms than the parent, who had earlier onset than the grandparent.
See also: additive genetic effects, complex trait.
Industry:Biology
A protein or part of a protein made of a chain of amino acids joined by a peptide bond..
Industry:Biology
